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Biotinamido-L-serine 2-acetamido-2-deoxy-α-D-galactopyranoside
Fmoc-Ser(α-D-GalNAc)-OH
/ α-D-Gal-Butyl-Carboxylic Acid / α-Gal-Bu-CO2H
including applications in enzyme replacement therapy (ERT) for lysosomal storage disorders and in lysosome-targeting chimera (LYTAC) approaches for targeted protein degradation
Sialyl Tn or STn (Neu5Acα2-6GalNAcα-O-Thr) at Thr144
AG152015: β-D-GalNAc-Pentyl-Carboxylic Acid (Peracetate) Pack Size:50 mg Biotinamido-L-serine 2-acetamido-2-deoxy-α-D-galactopyranosideC20H31NO11 461. 46 A peracetylated D N acetylgalactosamine (GalNAc) ligand equipped with a terminal carboxylic acid through a pentyl spacer, with the sugar hydroxyl groups protected as acetate esters. The peracetate groups increase lipophilicity to facilitate cell membrane permeability. The carboxylic acid can be activated to NHS, sulfo NHS, or pentafluorophenyl (PFP) esters and reacted with amine functionalized platforms or lysine residues on
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