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It can only be answered by mass removal like Damnation

There's always a chance the opponent will simply manifest a new creature to resume the offensive, making Reality Shift a bit iffy among Commander's best removal spells

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For example, Tekuthal, Inquiry Dominus mentions proliferate, but isnt a proliferate card for the purposes of this list

Being colorless and the ability to get this with Tinker made it even worse than most similar threats, and the only thing that kept it from taking over the world completely for the week or so it was legal was that there was a second combination deck built around High Tide running around that was just as bad